Conformation of BCL-XL upon membrane-integration

BCL-XL is an anti-apoptotic BCL-2 family protein found both in the cytosol and bound to intracellular membranes. Structural studies of BCL-XL have advanced by deleting its hydrophobic C-terminus and adding detergents to enhance solubility. However, since the C-terminus is essential for function and...

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Udgivet i:J Mol Biol
Main Authors: Yao, Yong, Fujimoto, Lynn M., Hirshman, Nathan, Bobkov, Andrey A., Antignani, Antonella, Youle, Richard J., Marassi, Francesca M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457587/
https://ncbi.nlm.nih.gov/pubmed/25731750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.02.019
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