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Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL

BCL-XL is a dominant inhibitor of apoptosis and a significant anti-cancer drug target. Endogenous BCL-XL is integral to the mitochondrial outer membrane (MOM). Indeed, BCL-XL reconstituted in detergent-free lipid bilayer nanodiscs is anchored to the nanodisc lipid bilayer membrane by tight associati...

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Detalhes bibliográficos
Publicado no:Protein Expr Purif
Main Authors: Yao, Yong, Nisan, Danielle, Fujimoto, Lynn M., Antignani, Antonella, Barnes, Ashley, Tjandra, Nico, Youle, Richard J., Marassi, Francesca M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842142/
https://ncbi.nlm.nih.gov/pubmed/26923059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2016.02.010
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