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Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL
The BH3-only BCL-2 family protein BID is activated by caspase-8 cleavage upon engagement of cell surface death receptors. The resulting 15 kDa C-terminal fragment, tBID, translocates to mitochondria triggering the release of cytotoxic molecules and cell death. The pro-apoptotic activity of tBID is r...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762941/ https://ncbi.nlm.nih.gov/pubmed/19670908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901171n |
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