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Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL

The BH3-only BCL-2 family protein BID is activated by caspase-8 cleavage upon engagement of cell surface death receptors. The resulting 15 kDa C-terminal fragment, tBID, translocates to mitochondria triggering the release of cytotoxic molecules and cell death. The pro-apoptotic activity of tBID is r...

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Bibliografiske detaljer
Main Authors: Yao, Yong, Bobkov, Andrey A., Plesniak, Leigh A., Marassi, Francesca M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762941/
https://ncbi.nlm.nih.gov/pubmed/19670908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901171n
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