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Binding Affinities Controlled by Shifting Conformational Equilibria: Opportunities and Limitations
Conformational selection is an established mechanism in molecular recognition. Despite its power to explain binding events, it is hardly used in protein/ligand design to modulate molecular recognition. Here, we explore the opportunities and limitations of design by conformational selection. Using ap...
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| Vydáno v: | Biophys J |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457000/ https://ncbi.nlm.nih.gov/pubmed/25992736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.04.012 |
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