Conformational equilibria and intrinsic affinities define integrin activation

We show that the three conformational states of integrin α(5)β(1) have discrete free energies and define activation by measuring intrinsic affinities for ligand of each state and the equilibria linking them. The 5,000‐fold higher affinity of the extended‐open state than the bent‐closed and extended‐...

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Bibliografische gegevens
Gepubliceerd in:EMBO J
Hoofdauteurs: Li, Jing, Su, Yang, Xia, Wei, Qin, Yan, Humphries, Martin J, Vestweber, Dietmar, Cabañas, Carlos, Lu, Chafen, Springer, Timothy A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331762/
https://ncbi.nlm.nih.gov/pubmed/28122868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695803
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