Positive and Negative Design for Nonconsensus Protein-DNA Binding Affinity in the Vicinity of Functional Binding Sites

Recent experiments provide an unprecedented view of protein-DNA binding in yeast and human genomes at single-nucleotide resolution. These measurements, performed over large cell populations, show quite generally that sequence-specific transcription regulators with well-defined protein-DNA consensus...

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Bibliographic Details
Main Authors: Afek, Ariel, Lukatsky, David B.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2013
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822674/
https://ncbi.nlm.nih.gov/pubmed/24094406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.08.033
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