A Designed Conformational Shift To Control Protein Binding Specificity**

In a conformational selection scenario, manipulating the populations of binding-competent states should be expected to affect protein binding. We demonstrate how in silico designed point mutations within the core of ubiquitin, remote from the binding interface, change the binding specificity by shif...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Michielssens, Servaas, Peters, Jan Henning, Ban, David, Pratihar, Supriya, Seeliger, Daniel, Sharma, Monika, Giller, Karin, Sabo, Thomas Michael, Becker, Stefan, Lee, Donghan, Griesinger, Christian, de Groot, Bert L
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497613/
https://ncbi.nlm.nih.gov/pubmed/25115701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201403102
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