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Accurate and Rigorous Prediction of the Changes in Protein Free Energies in a Large‐Scale Mutation Scan

The prediction of mutation‐induced free‐energy changes in protein thermostability or protein–protein binding is of particular interest in the fields of protein design, biotechnology, and bioengineering. Herein, we achieve remarkable accuracy in a scan of 762 mutations estimating changes in protein t...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Gapsys, Vytautas, Michielssens, Servaas, Seeliger, Daniel, de Groot, Bert L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074281/
https://ncbi.nlm.nih.gov/pubmed/27122231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510054
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