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Challenges encountered applying equilibrium and non-equilibrium binding free energy calculations

Binding free energy calculations have become increasingly valuable to drive decision making in drug discovery projects. However, among other issues, inadequate sampling can reduce accuracy, limiting the value of the technique. In this paper we apply absolute binding free energy calculations to ligan...

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Bibliografiske detaljer
Udgivet i:J Phys Chem B
Main Authors: Baumann, Hannah M., Gapsys, Vytautas, de Groot, Bert L., Mobley, David L.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240641/
https://ncbi.nlm.nih.gov/pubmed/33905257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.0c10263
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