Loading...

Molecular architecture and mechanism of the anaphase-promoting complex

The ubiquitination of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister chromatid segregation, cytokinesis and the establishment of G1. The APC/C is an unusually large multimeric cullin-RING ligase. Its activity is strictly dependent on regulatory coa...

Full description

Saved in:
Bibliographic Details
Published in:Nature
Main Authors: Chang, Lei-Fu, Zhang, Ziguo, Yang, Jing, McLaughlin, Stephen H., Barford, David
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456660/
https://ncbi.nlm.nih.gov/pubmed/25043029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13543
Tags: Add Tag
No Tags, Be the first to tag this record!