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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
BACKGROUND: Recurrent malignant brain tumors (RMBTs) carry a poor prognosis. Dichloroacetate (DCA) activates mitochondrial oxidative metabolism and has shown activity against several human cancers. DESIGN: We conducted an open-label study of oral DCA in 15 adults with recurrent WHO grade III – IV gl...
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| Publicado no: | Invest New Drugs |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4455946/ https://ncbi.nlm.nih.gov/pubmed/24297161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-013-0047-4 |
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