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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer with metabolic imaging but might also be associated with the resistance to apoptosis that characterises cancer. The glycolytic phenotype in cancer appears to be the commo...

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Autors principals: Michelakis, E D, Webster, L, Mackey, J R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567082/
https://ncbi.nlm.nih.gov/pubmed/18766181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604554
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