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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer with metabolic imaging but might also be associated with the resistance to apoptosis that characterises cancer. The glycolytic phenotype in cancer appears to be the commo...

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Detalhes bibliográficos
Main Authors: Michelakis, E D, Webster, L, Mackey, J R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567082/
https://ncbi.nlm.nih.gov/pubmed/18766181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604554
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