Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans

BACKGROUND: Chloral hydrate (CH), a sedative and metabolite of the environmental contaminant trichloroethylene, is metabolized to trichloroacetic acid, trichloroethanol, and possibly dichloroacetate (DCA). DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to ma...

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Bibliographic Details
Published in:Drug Metabol Personal Ther
Main Authors: Shroads, Albert L., Coats, Bonnie S., Langaee, Taimour, Shuster, Jonathan J., Stacpoole, Peter W.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455930/
https://ncbi.nlm.nih.gov/pubmed/25283137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/dmdi-2014-0015
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