Ferroptosis as a p53-mediated activity during tumour suppression

Although p53–mediated cell–cycle arrest, senescence and apoptosis serve as critical barriers to cancer development, emerging evidence suggests that the metabolic activities of p53 are also important. Here we show that p53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non–apoptotic f...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Jiang, Le, Kon, Ning, Li, Tongyuan, Wang, Shang–Jui, Su, Tao, Hibshoosh, Hanina, Baer, Richard, Gu, Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455927/
https://ncbi.nlm.nih.gov/pubmed/25799988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14344
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