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Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence
Cell-cycle arrest, apoptosis, and senescence are widely accepted as major mechanisms by which p53 inhibits tumor formation. Nevertheless, it remains unclear whether they are rate-limiting steps in tumor suppression. Here, we have generated mice bearing lysine to arginine mutations at one (p53(K117R)...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688046/ https://ncbi.nlm.nih.gov/pubmed/22682249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.026 |
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