Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Although p53-mediated cell cycle arrest, senescence and apoptosis are well accepted as major tumor suppression mechanisms, the loss of these functions does not directly lead to tumorigenesis, suggesting that the precise roles of these canonical activities of p53 need to be redefined. Here, we report...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Li, Tongyuan, Liu, Xiangyu, Jiang, Le, Manfredi, James, Zha, Shan, Gu, Wei
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Priority Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914251/
https://ncbi.nlm.nih.gov/pubmed/26943586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7864
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