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Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Although p53-mediated cell cycle arrest, senescence and apoptosis are well accepted as major tumor suppression mechanisms, the loss of these functions does not directly lead to tumorigenesis, suggesting that the precise roles of these canonical activities of p53 need to be redefined. Here, we report...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Tongyuan, Liu, Xiangyu, Jiang, Le, Manfredi, James, Zha, Shan, Gu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914251/
https://ncbi.nlm.nih.gov/pubmed/26943586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7864
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