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Ferroptosis as a p53-mediated activity during tumour suppression
Although p53–mediated cell–cycle arrest, senescence and apoptosis serve as critical barriers to cancer development, emerging evidence suggests that the metabolic activities of p53 are also important. Here we show that p53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non–apoptotic f...
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| Опубликовано в: : | Nature |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4455927/ https://ncbi.nlm.nih.gov/pubmed/25799988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14344 |
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