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Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity
The ubiquitin-proteasome system (UPS) is the primary mechanism by which intracellular proteins, transcription factors, and many proteotoxic proteins with aggregation-prone structures are degraded. The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome a...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4455164/ https://ncbi.nlm.nih.gov/pubmed/26041011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10757 |
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