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Nutlin-3 down-regulates Retinoblastoma protein expression and inhibits muscle cell differentiation
The p53 tumor suppressor gene plays a critical role in regulation of proliferation, cell death and differentiation. The MDM2 oncoprotein is a major negative regulator for p53 by binding to and targeting p53 for proteasome-mediated degradation. The small molecule inhibitor, nutlin-3, disrupts MDM2-p5...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4454893/ https://ncbi.nlm.nih.gov/pubmed/25871794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.04.024 |
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