Nutlin-3 Affects Expression and Function of Retinoblastoma Protein: ROLE OF RETINOBLASTOMA PROTEIN IN CELLULAR RESPONSE TO NUTLIN-3

The retinoblastoma protein (Rb) plays a pivotal role in regulating cell proliferation and apoptosis. Nutlin-3, a small molecule MDM2 antagonist blocking interaction between MDM2 and p53, activates p53 resulting in cell growth arrest or apoptosis in various cancer cells. However, the molecular basis...

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Autors principals: Du, Wei, Wu, Junfeng, Walsh, Erica M., Zhang, Yujun, Chen, Chang Yan, Xiao, Zhi-Xiong Jim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Biomolecular Networks
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785319/
https://ncbi.nlm.nih.gov/pubmed/19648117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046904
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