SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

Several molecular mechanisms have been proposed to explain trinucleotide repeat expansions. Here we show that in yeast srs2Δ cells, CTG repeats undergo both expansions and contractions, and they show increased chromosomal fragility. Deletion of RAD52 or RAD51 suppresses these phenotypes, suggesting...

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Bibliografiske detaljer
Udgivet i:Nat Struct Mol Biol
Main Authors: Kerrest, Alix, Anand, Ranjith P, Sundararajan, Rangapriya, Bermejo, Rodrigo, Liberi, Giordano, Dujon, Bernard, Freudenreich, Catherine H, Richard, Guy-Franck
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454460/
https://ncbi.nlm.nih.gov/pubmed/19136956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1544
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