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SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
Several molecular mechanisms have been proposed to explain trinucleotide repeat expansions. Here we show that in yeast srs2Δ cells, CTG repeats undergo both expansions and contractions, and they show increased chromosomal fragility. Deletion of RAD52 or RAD51 suppresses these phenotypes, suggesting...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4454460/ https://ncbi.nlm.nih.gov/pubmed/19136956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1544 |
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