SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

Several molecular mechanisms have been proposed to explain trinucleotide repeat expansions. Here we show that in yeast srs2Δ cells, CTG repeats undergo both expansions and contractions, and they show increased chromosomal fragility. Deletion of RAD52 or RAD51 suppresses these phenotypes, suggesting...

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Bibliographic Details
Published in:	Nat Struct Mol Biol
Main Authors:	Kerrest, Alix, Anand, Ranjith P, Sundararajan, Rangapriya, Bermejo, Rodrigo, Liberi, Giordano, Dujon, Bernard, Freudenreich, Catherine H, Richard, Guy-Franck
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4454460/ https://ncbi.nlm.nih.gov/pubmed/19136956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1544
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SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

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