Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain

Endostatin (ES) inhibits angiogenesis, reducing tumor growth in animal models. However, it has low therapeutic effect in human clinical trials. BAX is a member of the BCL-2 family of proteins; its proapoptotic (BH3) domain interacts with other members of the family in the cytoplasm, to induce apopto...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Chura-Chambi, R M, Bellini, M H, Jacysyn, J F, Andrade, L N, Medina, L P, Prieto-da-Silva, Á R B, Amarante-Mendes, G P, Morganti, L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454297/
https://ncbi.nlm.nih.gov/pubmed/25118931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.309
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