Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain

Endostatin (ES) inhibits angiogenesis, reducing tumor growth in animal models. However, it has low therapeutic effect in human clinical trials. BAX is a member of the BCL-2 family of proteins; its proapoptotic (BH3) domain interacts with other members of the family in the cytoplasm, to induce apopto...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Chura-Chambi, R M, Bellini, M H, Jacysyn, J F, Andrade, L N, Medina, L P, Prieto-da-Silva, Á R B, Amarante-Mendes, G P, Morganti, L
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454297/
https://ncbi.nlm.nih.gov/pubmed/25118931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.309
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