Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain

Endostatin (ES) inhibits angiogenesis, reducing tumor growth in animal models. However, it has low therapeutic effect in human clinical trials. BAX is a member of the BCL-2 family of proteins; its proapoptotic (BH3) domain interacts with other members of the family in the cytoplasm, to induce apopto...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chura-Chambi, R M, Bellini, M H, Jacysyn, J F, Andrade, L N, Medina, L P, Prieto-da-Silva, Á R B, Amarante-Mendes, G P, Morganti, L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454297/
https://ncbi.nlm.nih.gov/pubmed/25118931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.309
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