BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK

BH3 only proteins trigger cell death by interacting with pro- and anti-apoptotic members of the BCL-2 family of proteins. Here we report that BH3 peptides corresponding to the death domain of BH3-only proteins, which bind all the pro-survival BCL-2 family proteins, induce cell death in the absence o...

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Detalhes bibliográficos
Main Authors: Shroff, Emelyn H., Snyder, Colleen M., Budinger, G. R. Scott, Jain, Manu, Chew, Teng-Leong, Khuon, Satya, Perlman, Harris, Chandel, Navdeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681411/
https://ncbi.nlm.nih.gov/pubmed/19468307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005646
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