MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

BACKGROUND: Colorectal cancers arise from benign adenomas, although not all adenomas progress to cancer and there are marked interpatient differences in disease progression. We have previously associated KRAS mutations with disease progression and reduced survival in colorectal cancer patients. METH...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Amankwatia, E B, Chakravarty, P, Carey, F A, Weidlich, S, Steele, R J C, Munro, A J, Wolf, C R, Smith, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453675/
https://ncbi.nlm.nih.gov/pubmed/25919696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.125
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