Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa

BACKGROUND: Oxaliplatin and 5-fluorouracil (5-FU) currently form the backbone of conservative treatment in patients with metastatic colorectal cancer. Tumour responses to these agents are highly variable, but the underlying mechanisms are poorly understood. Our previous results have indicated that o...

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Detalhes bibliográficos
Main Authors: de Bruijn, M T, Raats, D A E, Hoogwater, F J H, van Houdt, W J, Cameron, K, Medema, J P, Borel Rinkes, I H M, Kranenburg, O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856010/
https://ncbi.nlm.nih.gov/pubmed/20354524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605633
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