Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa

BACKGROUND: Oxaliplatin and 5-fluorouracil (5-FU) currently form the backbone of conservative treatment in patients with metastatic colorectal cancer. Tumour responses to these agents are highly variable, but the underlying mechanisms are poorly understood. Our previous results have indicated that o...

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Xehetasun bibliografikoak
Egile Nagusiak: de Bruijn, M T, Raats, D A E, Hoogwater, F J H, van Houdt, W J, Cameron, K, Medema, J P, Borel Rinkes, I H M, Kranenburg, O
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2010
Gaiak:
Translational Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856010/
https://ncbi.nlm.nih.gov/pubmed/20354524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605633
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