Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells

BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumours of bone. Because of their resistance to conventional chemotherapy and radiotherapy, currently no treatment strategies exist for unresectable and metastatic chondrosarcoma. Previously, PI3K/AKT/GSK3β and Src kinase pathways were show...

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Detalhes bibliográficos
Main Authors: van Oosterwijk, J G, van Ruler, M A J H, Briaire-de Bruijn, I H, Herpers, B, Gelderblom, H, van de Water, B, Bovée, J V M G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778302/
https://ncbi.nlm.nih.gov/pubmed/23922104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.451
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