O(6)-Methylguanine-DNA methyltransferase status in neuroendocrine tumours: prognostic relevance and association with response to alkylating agents

BACKGROUND: O(6)-Methylguanine-DNA methyltransferase (MGMT) loss of expression has been suggested to be predictive of response to temozolomide in neuroendocrine tumours (NETs), but so far, only limited data are available. We evaluated the prognostic and predictive value of MGMT status, assessed by t...

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Publicat a:Br J Cancer
Autors principals: Walter, T, van Brakel, B, Vercherat, C, Hervieu, V, Forestier, J, Chayvialle, J-A, Molin, Y, Lombard-Bohas, C, Joly, M-O, Scoazec, J-Y
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453664/
https://ncbi.nlm.nih.gov/pubmed/25584486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.660
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