O(6)-Methylguanine-DNA methyltransferase status in neuroendocrine tumours: prognostic relevance and association with response to alkylating agents

BACKGROUND: O(6)-Methylguanine-DNA methyltransferase (MGMT) loss of expression has been suggested to be predictive of response to temozolomide in neuroendocrine tumours (NETs), but so far, only limited data are available. We evaluated the prognostic and predictive value of MGMT status, assessed by t...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Walter, T, van Brakel, B, Vercherat, C, Hervieu, V, Forestier, J, Chayvialle, J-A, Molin, Y, Lombard-Bohas, C, Joly, M-O, Scoazec, J-Y
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453664/
https://ncbi.nlm.nih.gov/pubmed/25584486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.660
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