DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O(6)-Methylguanine-DNA Methyltransferase Status

Hepatocellular carcinoma (HCC) is increasingly important in the United States as the incidence rate rose over the last 30 years. C3HeB/FeJ mice serve as a unique model to study HCC tumorigenesis because they mimic human HCC with delayed onset, male gender bias, a ~50% incidence, and susceptibility t...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Herzig, Maryanne C.S., Zavadil, Jessica A., Street, Karah, Hildreth, Kim, Drinkwater, Norman R, Reddick, Traci, Herbert, Damon C., Hanes, Martha, McMahan, C. Alex, Reddick, Robert, Walter, Christi A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777656/
https://ncbi.nlm.nih.gov/pubmed/26667451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0251
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