O(6)-methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well Differentiated Pancreatic Neuroendocrine Tumors

OBJECTIVES: Alkylating agents have activity in well differentiated pancreatic neuroendocrine tumors (WD panNETs). In glioblastoma multiforme, decreased activity of O(6)-methylguanine DNA methyltransferase (MGMT) predicts response; in panNETs, MGMT relevance is unknown. METHODS: We identified patient...

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Publicado no:Pancreas
Main Authors: Raj, Nitya, Klimstra, David S., Horvat, Natally, Zhang, Liying, Chou, Joanne F., Capanu, Marinela, Basturk, Olca, Do, Richard Kinh Gian, Allen, Peter J., Reidy-Lagunes, Diane
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509357/
https://ncbi.nlm.nih.gov/pubmed/28609363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000842
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