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Asymmetric conformational maturation of HIV-1 reverse transcriptase

HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural roles, thereby minimizing its coding requirements. This ambiguity introduces folding challenges that are met by a complex maturation process. We h...

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Foilsithe in:eLife
Main Authors: Zheng, Xunhai, Perera, Lalith, Mueller, Geoffrey A, DeRose, Eugene F, London, Robert E
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452869/
https://ncbi.nlm.nih.gov/pubmed/26037594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06359
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