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Asymmetric conformational maturation of HIV-1 reverse transcriptase
HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural roles, thereby minimizing its coding requirements. This ambiguity introduces folding challenges that are met by a complex maturation process. We h...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452869/ https://ncbi.nlm.nih.gov/pubmed/26037594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06359 |
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