Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

Interfering with LPS binding by the co-receptor protein myeloid differentiation factor 2 (MD-2) represents a useful approach for down-regulation of MD-2·TLR4-mediated innate immune signaling, which is implicated in the pathogenesis of a variety of human diseases, including sepsis syndrome. The antag...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Innate Immun
Main Authors: Garate, Jose Antonio, Stöckl, Johannes, del Carmen Fernández-Alonso, María, Artner, Daniel, Haegman, Mira, Oostenbrink, Chris, Jiménez-Barbero, Jesús, Beyaert, Rudi, Heine, Holger, Kosma, Paul, Zamyatina, Alla
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2015
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452626/
https://ncbi.nlm.nih.gov/pubmed/25394365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425914550426
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker