Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

[Image: see text] Recognition of the lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria, by the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD-2) complex is essential for the control of bacterial infection. A pro-inflammatory signaling casca...

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Hlavní autoři: Artner, Daniel, Oblak, Alja, Ittig, Simon, Garate, Jose Antonio, Horvat, Simon, Arrieumerlou, Cécile, Hofinger, Andreas, Oostenbrink, Chris, Jerala, Roman, Kosma, Paul, Zamyatina, Alla
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833292/
https://ncbi.nlm.nih.gov/pubmed/23952219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4003199
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