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Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists
[Image: see text] The endotoxic portion of lipopolysaccharide (LPS), a glycophospholipid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)–myeloid differentiation factor 2 (MD-2) complex, which results in pro-inflammatory immune signaling. To unveil the structural requirements for...
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| Główni autorzy: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2014
|
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4191062/ https://ncbi.nlm.nih.gov/pubmed/25252784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500946r |
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