Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists

[Image: see text] The endotoxic portion of lipopolysaccharide (LPS), a glycophospholipid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)–myeloid differentiation factor 2 (MD-2) complex, which results in pro-inflammatory immune signaling. To unveil the structural requirements for...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Adanitsch, Florian, Ittig, Simon, Stöckl, Johannes, Oblak, Alja, Haegman, Mira, Jerala, Roman, Beyaert, Rudi, Kosma, Paul, Zamyatina, Alla
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191062/
https://ncbi.nlm.nih.gov/pubmed/25252784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500946r
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky