Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists

[Image: see text] The endotoxic portion of lipopolysaccharide (LPS), a glycophospholipid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)–myeloid differentiation factor 2 (MD-2) complex, which results in pro-inflammatory immune signaling. To unveil the structural requirements for...

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Päätekijät: Adanitsch, Florian, Ittig, Simon, Stöckl, Johannes, Oblak, Alja, Haegman, Mira, Jerala, Roman, Beyaert, Rudi, Kosma, Paul, Zamyatina, Alla
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191062/
https://ncbi.nlm.nih.gov/pubmed/25252784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500946r
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