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The GlcN6P cofactor serves multiple catalytic roles in the glmS ribozyme

RNA enzymes have remarkably diverse biological roles despite having limited chemical diversity. Protein enzymes enhance their reactivity through recruitment of cofactors. The naturally occurring glmS ribozyme uses the glucosamine-6-phosphate (GlcN6P) organic cofactor for phosphodiester bond cleavage...

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Dettagli Bibliografici
Pubblicato in:Nat Chem Biol
Autori principali: Bingaman, Jamie L., Zhang, Sixue, Stevens, David R., Yennawar, Neela H., Hammes-Schiffer, Sharon, Bevilacqua, Philip C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362308/
https://ncbi.nlm.nih.gov/pubmed/28192411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2300
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