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The GlcN6P cofactor serves multiple catalytic roles in the glmS ribozyme

RNA enzymes have remarkably diverse biological roles despite having limited chemical diversity. Protein enzymes enhance their reactivity through recruitment of cofactors. The naturally occurring glmS ribozyme uses the glucosamine-6-phosphate (GlcN6P) organic cofactor for phosphodiester bond cleavage...

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Detalles Bibliográficos
Publicado en:Nat Chem Biol
Main Authors: Bingaman, Jamie L., Zhang, Sixue, Stevens, David R., Yennawar, Neela H., Hammes-Schiffer, Sharon, Bevilacqua, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362308/
https://ncbi.nlm.nih.gov/pubmed/28192411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2300
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