An evaluation of the brain distribution of [(11)C]GSK1034702, a muscarinic-1 (M(1)) positive allosteric modulator in the living human brain using positron emission tomography

BACKGROUND: The ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB) provides valuable information for de-risking drug development of new molecules. Here, we present a study, where a suitable positron emission tomography (PET) ligand wa...

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Foilsithe in:EJNMMI Res
Main Authors: Ridler, Khanum, Cunningham, Vincent, Huiban, Mickael, Martarello, Laurent, Pampols-Maso, Sabina, Passchier, Jan, Gunn, Roger N, Searle, Graham, Abi-Dargham, Anissa, Slifstein, Mark, Watson, Jeanette, Laruelle, Marc, Rabiner, Eugenii A
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer Berlin Heidelberg 2014
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452589/
https://ncbi.nlm.nih.gov/pubmed/26116126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-014-0066-y
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