Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A(2) (Lp-PLA(2)) Inhibitor [(18)F]GSK2647544 in Healthy Male Subjects

PURPOSE: GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), which was in development as a potential treatment for Alzheimer’s disease (AD). In order to refine therapeutic dose predictions and confirm brain penetration, a radiolabelled form of the...

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Detalhes bibliográficos
Publicado no:Mol Imaging Biol
Main Authors: Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew P., Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii A., Lockhart, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209404/
https://ncbi.nlm.nih.gov/pubmed/27402093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-016-0982-5
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