Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers

Abstract. Objective: To evaluate in healthy volunteers the safety, pharmacokinetics (PK), pharmacodynamics (PD), and drug-drug interaction (DDI) potential of GSK2647544, (a selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor). Methods: Study 1 was a single-blind, randomized, placeb...

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Publicado en:Int J Clin Pharmacol Ther
Autores principales: Wu, Kai, Xu, Jianfeng, Fong, Regan, Yao, Xiaozhou, Xu, Yanmei, Guiney, William, Gray, Frank, Lockhart, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: Dustri-Verlag Dr. Karl Feistle 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299597/
https://ncbi.nlm.nih.gov/pubmed/27719741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5414/CP202565
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