Metformin and daclatasvir: absence of a pharmacokinetic–pharmacodynamic drug interaction in healthy volunteers

AIM: The aim of the present study was to evaluate the effect of the proposed organic cation transporter (OCT) inhibitor daclatasvir on the pharmacokinetics and pharmacodynamics of the OCT substrate metformin. METHODS: This was an open‐label, two‐period, randomized, crossover trial in 20 healthy subj...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Smolders, Elise J., Colbers, Angela, de Kanter, Clara T. M. M., Velthoven‐Graafland, Kirsten, Wolberink, Leonie T., van Ewijk‐Beneken Kolmer, Noor, Drenth, Joost P. H., Aarnoutse, Rob E., Tack, Cees J., Burger, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595943/
https://ncbi.nlm.nih.gov/pubmed/28474741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13323
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