Rifampicin Alters Metformin Plasma Exposure but Not Blood Glucose Levels in Diabetic Tuberculosis Patients

The pharmacokinetic (PK) and clinical implications of combining metformin with rifampicin are relevant to increasing numbers of patients with diabetic tuberculosis (TB) across the world and are yet unclear. We assessed the impact of rifampicin on metformin PKs and its glucose‐lowering effect in pati...

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Udgivet i:Clin Pharmacol Ther
Main Authors: te Brake, Lindsey H.M., Yunivita, Vycke, Livia, Resvi, Soetedjo, Nanny, van Ewijk‐Beneken Kolmer, Eleonora, Koenderink, Jan B., Burger, David M., Santoso, Prayudi, van Crevel, Reinout, Alisjahbana, Bachti, Aarnoutse, Rob E., Ruslami, Rovina
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587702/
https://ncbi.nlm.nih.gov/pubmed/30222857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1232
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