Rifampicin Alters Metformin Plasma Exposure but Not Blood Glucose Levels in Diabetic Tuberculosis Patients

The pharmacokinetic (PK) and clinical implications of combining metformin with rifampicin are relevant to increasing numbers of patients with diabetic tuberculosis (TB) across the world and are yet unclear. We assessed the impact of rifampicin on metformin PKs and its glucose‐lowering effect in pati...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: te Brake, Lindsey H.M., Yunivita, Vycke, Livia, Resvi, Soetedjo, Nanny, van Ewijk‐Beneken Kolmer, Eleonora, Koenderink, Jan B., Burger, David M., Santoso, Prayudi, van Crevel, Reinout, Alisjahbana, Bachti, Aarnoutse, Rob E., Ruslami, Rovina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587702/
https://ncbi.nlm.nih.gov/pubmed/30222857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1232
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