Rifampicin Alters Metformin Plasma Exposure but Not Blood Glucose Levels in Diabetic Tuberculosis Patients

The pharmacokinetic (PK) and clinical implications of combining metformin with rifampicin are relevant to increasing numbers of patients with diabetic tuberculosis (TB) across the world and are yet unclear. We assessed the impact of rifampicin on metformin PKs and its glucose‐lowering effect in pati...

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Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: te Brake, Lindsey H.M., Yunivita, Vycke, Livia, Resvi, Soetedjo, Nanny, van Ewijk‐Beneken Kolmer, Eleonora, Koenderink, Jan B., Burger, David M., Santoso, Prayudi, van Crevel, Reinout, Alisjahbana, Bachti, Aarnoutse, Rob E., Ruslami, Rovina
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587702/
https://ncbi.nlm.nih.gov/pubmed/30222857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1232
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