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Concomitant Intake of Coca‐Cola to Manage the Drug–Drug Interaction Between Velpatasvir and Omeprazole Studied in Healthy Volunteers

We aimed to evaluate the effect of the acid beverage Coca‐Cola on the pharmacokinetics of velpatasvir (VEL) when given with omeprazole. This was an open‐label, randomized, crossover trial in 11 healthy adults. A single dose of sofosbuvir/velpatasvir (SOF/VEL) 400/100 mg was administered alone (refer...

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Détails bibliographiques
Publié dans:Clin Pharmacol Ther
Auteurs principaux: van Seyen, Minou, Colbers, Angela, Abbink, Evertine J., Drenth, Joost P.H., Burger, David M.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851656/
https://ncbi.nlm.nih.gov/pubmed/31313296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1569
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