Pharmacokinetic similarity demonstrated after crushing of the elbasvir/grazoprevir fixed-dose combination tablet for HCV infection

BACKGROUND: Finding a suitable treatment for HCV patients with swallowing disorders is still a major challenge. In practice, direct-acting antivirals are crushed without knowledge of adequate absorption. Crushing can alter drug exposure, possibly leading to treatment failure, development of resistan...

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Pubblicato in:J Antimicrob Chemother
Autori principali: Pijnenburg, Daniëlle W M, van Seyen, Minou, Abbink, Evertine J, Colbers, Angela, Drenth, Joost P H, Burger, David M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443725/
https://ncbi.nlm.nih.gov/pubmed/32544221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa230
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