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Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy

Neuropathic pain treatment remains a challenge because pathomechanism is not fully understood. It is believed that glial activation and increased spinal nociceptive factors are crucial for neuropathy. We investigated the effect of parthenolide (PTL) on the chronic constriction injury to the sciatic...

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Détails bibliographiques
Publié dans:Neural Plast
Auteurs principaux: Popiolek-Barczyk, Katarzyna, Kolosowska, Natalia, Piotrowska, Anna, Makuch, Wioletta, Rojewska, Ewelina, Jurga, Agnieszka M., Pilat, Dominika, Mika, Joanna
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452088/
https://ncbi.nlm.nih.gov/pubmed/26090236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/676473
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