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Rapid Identification of Improved Protein Ligands Using Peptoid Microarrays
A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via Click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.
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| Publicado en: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452005/ https://ncbi.nlm.nih.gov/pubmed/19380225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.153 |
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